Yuwen Ting, Chi-Te Liu, Kai-Yin Lo, Teu-Ching Shi, Kuan-Chen Cheng*
Adelaide Maria de Souza Antunes, Marcelo Kropf*
This article uses concepts from technology management applied to health to identify and analyze the trends in new orthopedic implants. Using the technological information extracted from scientiﬁ c articles and patents indexed between 2000 and 2014 in the Web of Science and Derwent Innovations Index databases, respectively, we created a taxonomy to take account of these trends. (Bio) mechanical and orthopedic engineering technologies (60%), (nano) biomaterials technologies (20%), and (bio) chemical and (bio) pharmaceutical technologies (16%) represent the current trends in orthopedic prosthetics. The last two categories together correspond to the application of nanobiotechnology to new biomaterials for implants (32%) and indicate the future trends in orthopedic prosthetics. Technologies for testing and diagnostics account for just 4% of the total. These data are strategic, in that they indicate the development and production of new orthopedic technologies for the health sector in a global market for orthopedic implants expected to be worth some US$ 41.8 billion in 2016.
Irwandi Jaswir*, Fitri Octaviantic, Widya Lestarid, Ridar Hendrie
Water with special healing properties has been reported for generations to contain health beneﬁ ts and abilities to cure diseases. Water from locations including Nordenau in Germany and Lourdes in Paris have been analysed to deduce the special characteristics of the water that provide the healing properties. In this study, natural bedrock underground water from Baegunsan mountain in Idong- myeon, Pocheon- si, Gyeonggi- go, Korea was analysed for beneﬁ cial properties. The alkalescent hydrogen-water which is termed TaeCheongsu water was tested for superoxide anion radical scavenging activities (SOSA), size of water molecules, active hydrogen content, hydrogen peroxide degradation capability and dissolved oxygen content. The results for TaeCheongsu water was compared against tap water, Stephan water, Nordenauer water and Lourdes water. TaeCheongsu water showed superior results compared to other healing waters and against controls across all tests. Therefore, TaeCheongsu healing water is a high quality water with potential beneﬁ ts for health.
Luna Rizik, Yaron Ram, Ramez Danial*
Biomolecular computing, encompassing computations performed by molecules, proteins and DNA, is a central area of focus in Synthetic Biology research and development, which attempt to apply engineering design principles in living cells. Two major computation paradigms have been implemented so far in living cells - analog paradigm that computes with a continuous set of numbers and digital paradigm that computes with two-discreet set of numbers. Here, we analyze the biophysical and technological limits of large-scale gene networks created based on analog and digital computation in living cells. More specifi cally, we calculate the precision of analog systems and the noise margin of digital systems in living cells. We conclude that both systems are challenging to operate with low protein levels. To overcome this challenge, we show that analog systems should operate with a Hill coeffi cient smaller than 1 and digital systems should be buffered. Furthermore, an analytical description of a biophysical model recently developed for positive feedback linearization circuits and used in analog synthetic biology, is presented. Finally, we suggest new directions for engineering biological circuits capable of computation.
Biocore Publishing Group
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