L.Nefyodov* P. Karavay, N. Karavay
On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
The Nigerian Civil War raged between 1967 and 1970. During this period, because of the Federal Government’s blockade of the secessionist Eastern Region, there was the disease called “kwashiorkor.” It was directly attributable to malnutrition and so was paragonimiasis. Both diseases presented remarkable features of pathogenesis including the author’s discovery of the responsible adult worms of Paragonimus uterobilateralis. It is concluded that, although international assistance programme was beneficial, well planned public policies would eliminate war and enthrone peace worldwide especially in Developing Countries.
Nourah Al Qahtani*, Hatoon Al Taif
A 27 years woman in her first pregnancy had an uncomplicated Caesarean section due to foetal distress of one of the twins. The postoperative period was complicated by Caesarean section uterine wall dehiscence, bacteraemia and generalized peritonitis. She was started on antibiotics. The main objective was to treat the infection and to try to avoid hysterectomy as the patient was strongly wishing to keep her uterus. CT scan guided aspiration of the peritoneal fluid was done with two drains. In addition to the patient’s refusal to have hysterectomy, she was also at a great risk for anaesthesia due to the development of bilateral pleural effusion, hepatosplenomegaly and marked thrombocytosis. After two weeks, she improved clinically. The pleural effusion, hepatosplenomegaly and the thrombocytosis disappeared. She had laparotomy to repair the uterine defect. This was done and the patients was discharged home in good condition.
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