Radhika Natarajan*, Ramya Ravindran, Mahesh Sonpethkar
Here we report a rare case of keratoconus in a lady, which was previously stable, but progressed following Hormone replacement therapy (HRT) given for menopausal symptoms. This is to stress on the importance of a close follow up of a keratoconus patient who is placed on HRT.
Mende Mensa*, Tarekegn Tadesse, Akililu Ayele
Drug use is a complex subject involving the prescriber, the dispenser, the patient and pharmaceutical institutions. It is influenced by factors such as drug availability, prescriber's experience, and knowledge of dispensers, health budget, cultural factors and many more. Inappropriate drug use is the problem of the whole world; however the degree of the problem is higher in developing countries like Ethiopia.
To assess drug use pattern by using who core drug use indicators at public hospitals in Gamo Gofa Zone, Southern Ethiopia September 2013.
Retrospective and prospective cross sectional study were used to collect data from prescriptions dispensed through the general outpatient pharmacies and Information for patients respectively. A pretested structured questionnaire was employed to collect information from prescription papers and respondents after obtaining a verbal consent. Data was entered, cleaned, edited and analysed using SPSS Version 16.0 statistical software package.
The average number of drugs per prescription was 1.77 in Arba Minch General Hospital and 1.95 in Chencha District hospital ranging from 1-5. Percentage of encounter with antibiotics was 292(48.67%) and 360(60.20%) respectively. The Percentage of drugs prescribed by generic name and from an essential drug list was 100%. The mean consultation time spent between the prescriber and patient was 3.82 minutes and 3.66 minutes respectively and the mean pharmacy dispensing time was 1.18 minutes and 1.33 minutes respectively. More than half Patients had knowledge on drug dispensed to them 60.0% and 52.0% respectively and none of drugs dispensed were adequately labelled.
In our study the labelling status of prescribed medicines was very poor and needs special attention. Dispensing time is very short and it could have influenced patient's knowledge on dispensed drugs. Furthermore designing strategies to improve availability of key essential drugs; establishing antimicrobial stewardship committee in both hospitals and improving drug and therapeutics committee by responsible bodies.
Dror Robinson*, Mustafa Yassin
The current case report describes regression of digital ischemia in thromboangiitis obliterans patient following high-dose medical cannabis therapy (MCT). MCT therapy was instituted as a pain-mitigating treatment when the patient refused amputation due to ischemic and infected foot. Three years later the digital ischemia has resolved leaving minimal scarring. The mechanism of action might be related to the anti-tobacco use effects of MCT as well as the anti-inflammatory action of CBD.
The endocannabinoid system is important in vascular system function via the CB-1 and CB-2 receptors that are widely distributed in the vascular system(1). The relationship between cannabis usage and vascular problems has not been fully elucidated. The current state of knowledge does not support a statistical association between increased incidence of myocardial infarction and cannabis use(2). Some authors have found that cannabis use is associated with cardiovascular problems and there is a 3.5 odds ratio of being a cannabis user in patients with thromboangiitis obliterans(3). However, this might not be causative but rather an attempt at therapy by the patients. In fact, a mechanism of action by activation of CB-2 receptors is likely to mitigate atherosclerosis. The possible mechanism involves CB2 receptors playing an important compensatory role in controlling tissue inflammation and injury in infiltrating monocytes/macrophages and leukocytes during various pathological conditions of the systems such as atherosclerosis and restenosis(4) These receptors limit inflammation and associated tissue injury. The current case report describes the use of high-dose cannabis (Medical Cannabis Therapy, MCT) as a therapy for severe thromboangiitis obliterans and results three years later.
Mahmoud Yaghoubi doust*, Halimeh Enayat, Amir Azarkamand, Parvin Gangi, Manouchehr Ghalandar
Family planning as a whole is the main Part of reproductive health and the key to the health of mothers, children, families, communities and societies, that One of the success factors in family planning and population control in Iran is male involvement . The main purpose of this study was to investigate the relationship between social - cultural factors with propensity of men to participate in family planning is in Baghmalek city. The research method is survey. The population of this study included all married men in baghmalek city in 2017. Sample was determined based on Coke ran frameof 320 people. The questionnaire is self-made, that with multistage cluster sampling among respondents was divided. In general, the findings show a correlation between the amount of piety, fear of side effects of contraceptives, and patriarchal gender attitudes of men to participate in family planning programs there were significant relationships. Stepwise multiple regression analysis shows that the changing attitudes of patriarchal gender have been most affected by the tendency of men to participate in family planning programs . Overall, the independent variables have been able to explain 43/25 percent of dependent variable.
Kafil Akhtar*, Mohammad Jaseem Hassan, Tamkeen Khan, Ghazala Mehdi
Yolk sac tumor is a rare neoplasm, which affects children and adolescents. Majority of the YSTs occur in the gonads, but about 20% have been found in variety of extragonadal sites such as mediastinum, retroperitoneum, neck and presacral areas. When exfoliative cytologic samples are considered, yolk sac tumors are most often identified in pleural, peritoneal, or pericardial fluids. Touch preparations (TPs) of intraoperative tissue have been used for cytologic diagnosis. Fine-needle aspiration (FNA) is not commonly used to study primary malignancies in the testis or ovary. However, this method is well suited to the evaluation of yolk sac tumor metastases and is a useful diagnostic method when applied to extragonadal primary lesions. We describe the cytomorphology of this tumor in ascitic fluid of an 18 year old female
Biocore Publishing Group
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