Numerous Studies Show: Not an Excess of Cholesterol, but First of all a Systemic Inflammation is
The Real Reason of Many Cardiovascular Diseases and of Sudden Death
At the end of August 2017, an important message appeared about the prevention and treatment of cardiovascular diseases (CVD)
A significant reduction in the risk of repeated heart attacks, strokes
and cardiovascular death was found among people receiving a targeted
anti-inflammatory drug that reduced inflammation, but did
not affect the cholesterol level. This message came from a team of
researchers from Harvard Brigham Branch and the Women’s Hospital
(BWH). Naturally, this group of researchers began the work
several years ago [1,2,3].
Scientists report a 15% reduction in the risk of cardiovascular
events, including fatal or non-fatal heart attacks and strokes, for
patients who received a dose of Canakinumab (ilaris): either 150
or 300 mg.
“For the first time, we were able to show conclusively that reducing
inflammation independent of cholesterol reduces the risk of
cardiovascular disease,” said Paul M. Ridker, director of the Center
for the Prevention of Cardiovascular Disease at BWH. This has
far-reaching consequences. Dr. Paul M. Ridker says that using a
completely new way of treating patients, aimed at inflammation,
we can significantly improve the results for some high-risk populations.
Ask the following questions. What does it mean for medicine?
What does it mean for patients?
From my point of view, this is a breakthrough in understanding the
direction of the search for the causes of the onset and treatment
of CVD. Perhaps after some time, it will be possible to find more
effective medicines for the treatment and prevention of CVD, including
metabolic syndrome and systemic inflammation. Let us
emphasize that this breakthrough, achieved at least for the last 30
years, was achieved by official medicine, not by a theory, not analytically,
but by trial and error with the testing of the effect of
various drugs (chemicals) on large groups of patients.
But on the other hand, this important message is an additional argument
in favor of the New Theory of CVD [4-17], which I have
been promoting since 2011. Discovery of scientists from Harvard
is an additional argument in understanding the mechanism of tissue
perfusion reduction and blood stasis, which, apparently, in itself
leads to many CVD.
My first report on the mechanism of congestion due to arteriovenous
anastomoses (AVA) or shunts was on the Internet portal
Here is the key phrase from the distant 2011 (18.07.2011): “... the
cause of” stagnation “in the microvascular veins - increased pressure
in the veins due to the opening of large artery-vein shunts and
the reverse flow of blood in the microvascular veins. There arises,
if I may say so, a “hydraulic lock”.
Now I would add: “There is a” hydraulic lock “, and if the effect
of this” lock “in some organs occurs regularly and lasts for
a long time, this condition leads to blocking blood circulation, to
insufficient perfusion of tissues, to metabolic syndrome. Blockage
of blood circulation leads to ischemia, at the same time, due
to fundamentally not identical local conditions of “capacity” of
blood vessels and taking into account the influence of the Earth’s
gravity, some of the organ cells may experience severe ischemia,
and the other part only a slight decrease in circulation.
perfusion and stasis can lead to the formation of many small foci
of pathology in the tissues and vessels (at the first stage reversible), to accumulation of toxins, to thrombosis, tissue necrosis, infection,
hyperglycemia, obesity, atherosclerosis, systemic inflammation
. “The conductor” of systemic inflammation is the whole
circulatory system, because stagnant dirty venous blood at certain
times of human life, for example, in the morning or after physical
or psychological loads, has the opportunity to enter the main flow
of both circulation circles and spread to all organs.”
I emphasize that in official medicine it is mistakenly believed
that the most probable cause of venous plethora and stagnation
of blood are certain obstructions in the veins in the form of blood
clots or embolus, due to the compression of the vein by a tumor,
scar, with an inadequate underdevelopment of the elastic framework
of the vein walls or their valvular apparatus, as well as in
the development of heart failure. I think that in this issue the cause
with the investigation changed places (with each other), and such
a mistakenly interpretation takes place in medicical science for
We can assume that for a large list of diseases, the primary blockage
of blood circulation in the organs is due to the opening and on
time of non-closing AVA, after which some groups of cells begin
to lack nutrition and oxygen. Apparently, it can be postulated that
there is a fundamental unevenness in the capillary circulation and
cellular nutrition in various organs in humans. Regular physical
movements and a change in the position of the body are necessary.
With the years gone by, this uneven supply increases, there are
Blocking leads to syndromes of a lack of metabolism, at the same
time hormonal regulation of homeostasis becomes activated, the
immune system reacts. After a while, systemic inflammation can
begin, which can lead to a “bouquet of diseases”, but according
to different scenarios for each individual. Since systemic inflammation
is primary, therefore, all subsequent numerous “diseases”
occur imperceptibly, sometimes against a background of mild inflammation,
i.e. with the masking of the “primary” systemic inflammation.
For several decades the question has been debated, what is the
mechanism of atherosclerosis. Which theory is correct: cholesterol
infiltration theory or inflammatory. A lot of data obtained recently,
are in favor of inflammatory theory.
I will give an interesting opinion about the causes of atherosclerosis,
which indirectly confirms my hypothesis about AVA and systemic
inflammation. I quote the opinion of a group of researchers
from the Research Clinical Institute of Pediatrics, Moscow .
“When comparing different theories of atherosclerosis, a legitimate
question arises: Is there a single cause of simultaneous inflammatory
process, dyslipidemia, proliferation of smooth muscle
cells, the formation of atherosclerotic plaques, endothelial damage?
It can be safely assumed that all carefully and deeply studied
pathogenetic mechanisms of the development of atherosclerosis
are secondary to a single factor that operates periodically, and the
increase in the symptoms of the disease occurs latently, wavy in
connection with the periodic improvement of detoxification of
the organism. Perhaps due to the safety of detoxifying abilities
in childhood, atherosclerosis is rarely diagnosed in children, although
the factors of cardiovascular damage can be detected early,
confirming the view that the development of atherosclerosis, metabolic
syndrome and cardiovascular diseases begins in childhood.
“In my opinion, the authors  gave a hopeful conclusion about
the possible existence of a single cause of many CVD! And according
to the New Theory - because of the disruption of the functioning
of AVA anastomoses.
In conclusion, a few practical tips.
What can a person do to prevent the manifestation of systemic
inflammation and increase life expectancy?
A healthy lifestyle is necessary: proper nutrition, physical activity,
including water, successful work, 7-8 hour sleep, moderate hardening,
breathing exercises with alternating sudden movements
of the diaphragm down, and after a while upwards. Down - for
outflow of stagnant venous blood above the diaphragm (from the
head and lungs), upwards - for outflow of stagnant venous blood
below the diaphragm (from the pelvic organs and legs). For sharp
movements of the diaphragm down, the exercise “Embrace the
shoulders” (the key and most effective exercise for Strelnikova)
is well suited
Here is a list of diseases, the pathogenesis of which stops the Strelnikova
To perform sudden movements of the diaphragm up you can use the following exercises:
Every 30-45 minutes take breaks when sitting at a computer. In the
evening to lose weight, you can use the “Pohudey (Weight Loss)”
Of course, this is an approximate list of recreational activities. In
the future, apparently, there will be more effective exercises and
pills. The main thing is understanding the mechanism of systemic
It becomes evident that theoretical and practical medicine needs
to be directed towards finding, observing and studying the functioning
of arteriovenous anastomoses (AVA) of different calibers.
It can be assumed that many diseases arise from open anastomoses,
because of uncontrolled leakage of arterial blood into veins
and intercellular fluid, due to overflow of the venous pool!
In addition, research is needed to develop new drugs, to prevent
and combat systemic inflammation.
It seems that the mechanism of systemic inflammation only now
begins to clear up, and medicine will very soon open new prospects
for development. So, the old problem of causality of systemic
inflammation is solved?
Take care of yourself!
- Ridker PM. Closing the Loop on Inflammation and Atherothrombosis:
Why Perform the Cirt and Cantos Trials? Transactions
of the American Clinical and Climatological Association.
- Ridker PM. Moving Beyond JUPITER: Will Inhibiting Inflammation
Reduce Vascular Event Rates? Current atherosclerosis
reports. 2013;15(1):10.1007/s11883-012-0295-3. doi:10.1007/
- Ridker PM. From CRP to IL-6 to IL-1: Moving Upstream To
Identify Novel Targets for Atheroprotection. Circulation research.
- Ermoshkin V.I. The new theory of heart failure. London, 15-
- Ermoshkin VI. New theory of arrhythmia. Conceptual substantiation
of arrhythmia mechanisms. Cardiometry; Issue 8; May 2016;
p.6–17; doi:10.12710/cardiometry.2016.8.617. http://www.cardiometry.net/issues/no8-may-2016/new-theory-of-arrhythmia
- Ermoshkin VI. The mechanism of bronchial asthma. Why do the
most serious asthma attacks occur at night? EC Cardiology, Volume
2 Issue 4 November 2016 https://www.ecronicon.com/eccy/
- Ermoshkin VI. Arteriovenous anastomoses and cardiovascular diseases. 8th Cardiovascular Nursing & Nurse Practitioners Meeting.
August 08-09, 2016 Las Vegas, USA, DOI: 10.4172/2155-9880.C1.045 http://www.omicsonline.org/proceedings/arteriovenous-anastomoses-and-cardiovascular-diseases-48866.html
- Ermoshkin VI. A New Theory of Certain Cardiovascular Diseases.
EC Cardiology, Volume 2 Issue 5 November 2016 https://
- Ermoshkin VI. Venous congestion due to large arteriovenous
anastomoses. 566 Chiswick High Road, London,
Greater London, W4 5YA, United Kingdom, DOI: 10.15761/
- Ermoshkin V (2017) The Cause of Some Cancers because of
the Open Arteriovenous Anastomoses. J Gastrointest Cancer Stromal Tumor 2: 1000111. https://www.omicsonline.org/open-access/
- Ermoshkin VI Problems of heart failure. Unexpected outcome.London, 15-17.03.2017. http://heartdiseases.conferenceseries.
- Ermoshkin VI. Arrhythmia and Cardiac Surgery. July 14-16, 2016, Brisbane, Australia. https://www.omicsonline.org/speaker/
- Ермошкин В.И. НОВАЯ ГИПОТЕЗА АРИТМИИ СЕРДЦА
У ЧЕЛОВЕКА. Стр 73. «Кардиостим-2016», Санкт-Петербург, 18 - 20 февраля 2016 (Russian) http://medicine.sportedu.ru/sites/
- Ermoshkin V.I. 2017. The new theory of cancer complements
ancient Chinese Qigong therapy. DOI: 10.15761/HCCT.1000106
- Ermoshkin VI. Heart transplantation mysteriously eliminates
arrhythmia. Cardiometry; Issue 8; May 2016; p.18–21; doi:10.12710/cardiometry.2016.8.1821.
- Ermoshkin Vladimir. Commercial offer for cardiac centers and potential investors. 2017, DOI: 10.15761/BEM.1000116 https://
- Ermoshkin V (2016) Pathological Role of the “Invisible”
Anastomoses. J Bioengineer & Biomedical Sci 6:209. doi:10.4172/2155-9538.1000209.
- Ермошкин Владимир Иванович, Механизм системного
воспаления у человека открылся: из-за утечки артериальнойкрови через артериовенозные анастомозы. В сборнике:“Научные открытия: международная on-line конференция”.
Дата публикации: 29.07.2017. Регистрация СМИ: ЭЛ №ФС77-
70153 от 30.06.2017 (предыдущее Эл№ФC77-49690 от 26
апреля 2012). (Russian) URL доступа: http://student.eee-science.
- E.A. Yuryeva, V.S. Sukhorukov, E.S. Vozdvizhenskaya, N.N.
Novikova. Atherosclerosis: Hypotheses and theories. Research
Clinical Institute of Pediatrics, Moscow; National Research Center “Kurchatov Institute”, РОССИЙСКИЙ ВЕСТНИК ПЕРИНАТОЛОГИИ И ПЕДИАТРИИ, 3, 2014, Moscow (Russian).