The Pathological Mechanism of Systemic Inflammation in Humans has opened. The Reason is Uncontrolled Leakage of Arterial Blood through Arteriovenous Anastomoses
This brief report provides some data on the status of the problem of systemic inflammation in humans. The situation with understanding
the causes of systemic inflammation and treatment of this disease progressed slowly. Our group has put forward a medical hypothesis,
confirmed by some medical supervision, which consists in the problem of functional disorders of arteriovenous anastomoses.
Systemic Inflammation, C-reactive Protein CRP, Heart Failure, Metabolic Syndrome, Atherosclerosis, Diabetes, Cancer
This report contains a brief analysis of the opinions on the causes
of the mysterious systemic inflammation in humans. In recent
years, the causes and mechanisms of systemic inflammation have
been suggested quite a lot, but so far there is no consensus and
The disease occurs in a large percentage of people at any age, but
usually after 20 years old. A particularly critical situation with the
prevalence of systemic inflammation has been observed in some
countries over the past 30 years. Why is this happening right now?
Materials and Methods:
Search for information through the Internet, study of classical and
modern main sources, participation at presentations on medical
conferences in 2012-2017, discussion of theoretical and clinical
issues with health experts of Russia.
I think that the complication of the problem of systemic inflammation
in people in recent years has arisen because in the same years
a boom of computerization began, the amount of physical work
in the office and at home decreased, and the number of stressful
But how is this related to the pathology of the circulation, with
systemic inflammation and abdominal obesity, taking into account
in turn that systemic inflammation correlates with a large number
of cardiovascular diseases?
It can be said that this tangle of problems for medicine was not yet
available for a correct understanding.
A detailed description of the problem of systemic inflammation
is given in articles[1, 2, 3, 4]. It can be concluded that many researchers
of different generations worked on the search for the
mechanism of occurrence and the solution of this problem, but as
a result they only paved the way for the approval of my theory. Of
course, all previous studies are not in vain, they will be more or
less included in the development of the New Theory.
The problem - at the macro level: the cause of systemic inflammation
should be considered physical interaction between the human
body with the vertical spine and the forces of gravity of the Earth.
Solve the problem at the microlevels (on the nervous, endocrine,
intracellular, intracellular, molecular), when hundreds of small
factors are discovered which, of course, are forcedly activated by
sedentary work and blood stasis, affect systemic inflammation interacting
with each other is very difficult.
As a physicist, I looked at this problem from the outside.
But first we postulate some factors that cause stagnation of blood
or, conversely, contribute to satisfactory blood pumping in the organs.
1) Venous blood in a strenuous posture or sitting ordinary person
for a long time (for example, when working at a computer) can not
rise from the pelvic area and legs to the right atrium only at the
expense of the negative pressure created by the heart itself. Sooner
or later, there are stagnation of blood and lymph, edema, especially
in the pelvic area and legs, in so-called “gravitational traps”, where
the cells are exposed to oxidative stress.
2) Venous blood of a physically working or walking (running)
human being rises to the level of the heart due to the contracting
muscles of the lower half of the body and legs. Venous valves play
a positive role here. But the main link of pumping is the expanding chest and movements of the respiratory diaphragm, especially its
sharp deep movements.
3) In a person standing in the water at the level of the neck or
chest, the hydrostatic pressure of water creates an inverse pressure
along the human body and promotes a good delivery of blood to
the heart. On the skin of the legs and superficial veins, there is a
pressure that pushes up the venous blood up to 100 mm Hg, and
to the pelvic region up to 50 mm Hg! That’s why swimming and
bathing in the water are very useful and recommended by all doctors
for prevention and treatment of CVD. (A similar, but much
less effective, analogue to pressure in water is compressible underwear
with a certain constant pressure.) It is interesting that it is
in the sea water, not on land, that vertebrates live 100-200 years
4) Extreme breathing exercises are very useful, for example, qigong
or yoga, to prevent stagnation of blood and lymph. Sharp
movements of the diaphragm upwards (with a sharp exhalation)
create powerful negative pressure waves in the veins of the lower
half of the body and extract dirty blood from the “gravitational
traps”. For a person, walks with quick steps are also useful and
any regular exercises (at least 5-6 times a week!). (For example,
conductors of orchestras have a constant load on muscles and a diaphragm
almost all life, therefore in the bulk they live the longest,
on the average 83.2 years is a record among all professions!)
5) In a person who is in a horizontal position, the venous pressure
in all organs is approximately equal. The blood from the “gravitational
traps” to which the human body includes the organs of the
small pelvis and legs is extracted quite easily by the negative pressure
of the heart and the movement of the diaphragm with quiet
breathing. Delivery of arterial blood to all organs is optimal. That’s
why a 7-8 hour sleep (but no more) is so useful, plus a periodic
daytime 5-10-minute rest in a lying position. That’s why a person
wakes up in the morning always with warm hands and feet. This
is why people who sleep less than 7 hours increase the likelihood
of various cardiovascular diseases and live less, as observed in the
The reason for my opinion is this: with a restless and short
sleep with frequent geting up, all stagnant venous blood does not
manage to get into the big circle of blood circulation. That’s why
exercises with horizontal position of the spine are so useful, that is
reason why such exercises easily leads to lose weight. For example,
when performing a complex of Nishi (Japan): lying on your
back with shaking of the limbs. Or when doing exercises at the
“Pohudey” complex. In such cases, under the influence of gravity
there is a good outflow of lymph, venous blood and intercellular
fluid from the lower half of the body and limbs to the center! Getting
rid of excess weight is not due to increased work of muscles,
but due to the extraction of stagnant venous blood from the lower
half of the body into the zone of the hollow veins.
From my point of view, the main macro factor contributing to
blood stasis is functioning arteriovenous anastomoses (AVA).
During periods of high physical or psychological stress, during
overeating or abusing alcohol, with a sharp increase in blood pressure
(BP) or in hypodynamia, in some organs may open AVA’s, for
example, between the superior mesenteric artery and portal vein
. In such a state, blood pressure sharply decreases, which saves
arterial vessels from mechanical damage, but volume of arterial
blood decrease and excess venous arises.
These same phenomena
are the cause of the notorious «jumps of blood pressure», later
called «Ermoshkin-Lukyanchenko syndrome». An increase in
venous pressure and venous volume leads to venous hyperemia
of the liver, to the sequential destruction of venous valves located
«upstream» from the point where AVA’s enters the veins. («Upstream»
or higher by along stream, it is means closer to the ground
or below the heart.) Damage to the valves leads to an additional
increase in pressure in the veins due to the growth of the hydrostatic
component. After a while, increased venous pressure can reach
the venules. The pressure gradient between arterioles and venules
becomes critically small.
There is a blockage of blood circulation,
the so-called hydraulic lock (bolt), some groups of cells are deprived
of the possibility of continuous consumption of oxygen,
nutrients and they are doomed to necrosis and apoptosis. To get
rid of increased blood pressure and blockage in the pelvic area,
rapid growth of collaterals, growth of white adipose tissue in the
mesentery, and other pathological changes begin. Apparently, it is
from the time of stagnation, edema and varicose that the «aging
process» of the body begins, sooner or later a «bouquet of diseases»
It is known that ischemia induces the generation of reactive oxygen
species, such as superoxide, peroxide, hydroxyl radical. In
turn, free radicals, in the form of active forms of oxygen (AFO),
cause damage to cell membranes, proteins and chromosomes.
Over time, longer stagnation of venous blood, ischemia of the
organs, edema, varicose veins, thromboses. Small veins and venules
are filled with blood, pathologically expand and begin to
flow blood into the intercellular space. During the night sleep, and
also taking into account some minimal physical activity during the
day, the organism of a passive person, his homeostasis can not
be brought to a satisfactory state. The no regenerated remains of
stagnant venous blood, affected by infection and other pathological
processes lead to systemic inflammation of almost the entire
cardiovascular system. The result of stagnation of blood, according
to the New Theory of CVD, are many well-known diseases:
metabolic syndrome, atherosclerosis, heart failure, mechanically
induced arrhythmia due to hollow venous overflow, abdominal
obesity, diabetes, cancer and other diseases[9, 10, 11, 12 , 13, 14,
15, 16, 17, 18, 19, 20, 21, 22].
It should be remembered, that over long sitting at the computer
can significantly worsen the health of the person, including adolescents.
There are many reports of sudden death of schoolchildren
with minimal stress in the lesson of physical education. There are
many reports of deaths in long-term multi-day computer games
without interruptions to normal sleep and exercise[23, 24]. The
reason is well explained by the New Theory: gambling (or long
work in the office) has an effect on the psyche, but the main thing
is that the many hours accumulation of venous blood in the lower
half of the body leads to its thrombosis and sudden death of a person
due to blood clots entering the arteries.
In addition, it can be safely assumed that infection, bacteria, AFO,
oxidized forms of lipids and proteins from the stagnation zones
along the bloodstream can penetrate the brain and cause Alzhei mer’s, Parkinson’s and others. I would like to emphasize that the
etiology and pathogenesis of these and other neurodegenerative
diseases are not yet known exactly. There is only a hypotheses[25,
26, 27], confirmed by some data, including my theory, obtained in
recent years. It turns out that the laws of physics play a major role
in the development of many CVDs!
Well, what did official medicine say a few years ago?
Development of critical conditions associated with microcirculatory
disorders: it is connect with the activation of endotheliocytes,
with a sludge, with microthrombosis, with vasodilation,
which in turn lead to decentering of blood circulation, hypovolemia,
tissue edema, vascular shock, hypoxia, acidosis, toxicosis
and etc. She said that systemic inflammation consists of a stress
response of the neuroendocrine system, primarily the hypothalamic-pituitary-adrenal
complex, the generalized manifestation of
the immune response, the acute phase response of the liver, and
the enhancement of leukocytopoiesis in the bone marrow. But the
original cause did not indicate. In fact, there is official medicine
confirms and supplements the New Theory of CVD, without naming
the main mechanism of its development, without seeing a common
system and the root cause. She believes that a special place in
systemic inflammation is occupied by the cytokine network, which
controls the development of immune and inflammatory reactivity.
The main producers of cytokines are T-cells and “inflammatory”
macrophages, and also to some extent other types of leukocytes,
endotheliocytes of postcapillary venules and many types of stromal
cells. The core of the syndrome of systemic inflammation is
the “inflammatory” restructuring of postcapillary venules and the
growing microcirculatory disorders in various organs and tissues,
leading to a change in many parameters of homeostasis[1, 2]. So,
each section and subsection of theoretical and practical medicine
was engaged in its “narrow” problem, so there was no one to make
systemic conclusions and generalizations.
Speaking about my New Theory, about the macro factors of inflammation,
it can be said that the process of systemic inflammation
begins precisely with an increase in venous pressure due to
open AVA’s, with the destruction of venous valves and postcapillary
venules, with stagnation of blood and lymph, with C-reactive
protein (CRP) level increase, with involvement in the pathological
process of many micro factors, in fact with the immune and
inflammatory reactivity of the body.
Based on these data, I believe that official medicine needs to focus
its efforts on a thorough study of AVA’s work under different conditions
of their growth and functioning.
I believe that a long, many centuries of medical history may end,
when almost all CVD were officially considered diseases with unknown
etiology and pathogenesis. Only sets of factors that contributed
to the development of different CVD were known. Now
it becomes clear that the main mechanism of almost all CVD is
one: non-optimal working arteriovenous anastomoses (AVA). That
is why many CVD are pairwise correlated. That is why, the medicines
for the prevention and treatment of many CVDs are also
largely the same. That’s why recommendations for physical activity
are also the same. That is why the age-dependent diseases (heartdisease, stroke, diabetes, cancer, Alzheimer’s disease) line up in
parallel lines on the chart, where the X-axis is the age group
(number of years), the Y-axis deaths per 100 000 people per year.
1) A more thorough study of the growth and functioning of arteriovenous
anastomoses (AVA) in humans is needed.
2) The pathophysiology of the body, namely metabolic syndrome,
systemic inflammation, atherosclerosis, other CVD can be caused
by leakage of arterial blood into the veins, increased venous pressure,
blockage of capillary circulation, stagnation of blood, lymph
and intercellular fluid, varicosity, micro necrosis of tissues. According
to the latest data, Alzheimer’s and Parkinson’s diseases
are also associated with infection, with bacteria, with pathologies
of protein structures.
3) Proceeding from the presented material, we can say: in order to
live for a long time, moderate physical activity or special exercises
are necessary for life. Training of respiratory organs, muscles, cardiovascular
system, including AVA, is necessary. You need your
favorite work and a good dream. It is impossible to rely only on
4) Now, apparently, we can say: old age is a disease, old age can
be treated! The mystery of man’s aging was in the anastomoses of
AVA, so the duration of active life can be increased.
5) But I will not run ahead: strictly speaking, while this is a hypothesis,
experiments and more substantial proofs are necessary. I
offer cooperation, joint study of the problems of CVD.
List of abbreviations:
CVD cardiovascular disease, AVA arteriovenous anastomose,
AFO active forms of oxygen, CRP C-reactive protein, BP blood pressure.
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